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. 2014 Oct 20;5:171. doi: 10.3389/fendo.2014.00171

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Copyright © 2014 Janssen, Zuidwijk, Kuster, Muller and Simonides.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The effects of T3 treatment on Myh-isoform expression and corresponding miRNAs. RNA was isolated from the LV of six hypothyroid (HO) and six hyperthyroid (HOT3) mice. The low Myh6 [(A), open bar] and high Myh7 mRNA levels [(B), open bar] are indicative of the low cardiac T3 state in the hypothyroid animals. The TH-responsiveness of both genes was evident from the shift in expression of Myh6 [(A), solid bar] and Myh7 [(B), solid bar] as a result of T3 treatment. MiRNAs 208a and 208b are located within Myh6 and Myh7. The expression pattern of miR-208a (C) and miR-208b (D) in these conditions is similar to the pattern of their host genes. HO set to 1, values are means ± SEM; *p < 0.05.