Table 3.
Acute and Late Toxicities Associated with Various Doses of Twice-weekly Gemcitabine Delivered during Radiotherapy
| Toxicities |
10 mg/m2 (n=6) |
20mg/m2 (n=8) |
33mg/m2 (n=3) |
50mg/m2 (n=4) |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| < 2 | 3 | 4 | < 2 | 3 | 4 | < 2 | 3 | 4 | < 2 | 3 | 4 | |
| Acute | ||||||||||||
| Hematologic | 6 | 8 | 2 | 1 | 4 | |||||||
| Mucosal | 3 | 3 | 3 | 3 | 2 | 1 | 1 | 1 | 2 | 2 | ||
| Pharyngeal | 2 | 4 | 7 | 1 | 1 | 2 | 1 | 1 | 2 | |||
| Skin | 4 | 2 | 1 | 7 | 1 | 2 | ||||||
| Larynx | 6 | 4 | 4 | 1 | 2 | 2 | 2 | |||||
| Late | ||||||||||||
| Mucosal | 6 | 5 | 2 | 1 | 1 | 2 | 2 | 2 | ||||
| Pharyngeal | 5 | 1 | 6 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | |
| Skin | 4 | 2 | 7 | 1 | 3 | 4 | ||||||
| Subcutaneous | 5 | 1 | 6 | 2 | 3 | 3 | 1 | |||||
| Larynx | 6 | 8 | 3 | 4 | ||||||||
| Dose-limiting | 0 | 2 | 2 | 2 | ||||||||
Values represent number of patients.