Table 1.
Wound Healing Assays in FaDu Cell Line
| Wound Size (Percentage of Healed Wound) |
|||||
|---|---|---|---|---|---|
| 2 Hours | 4 Hours | 8 Hours | 24 Hours | P Value at 24 Hours | |
| Nontreatment | 5.80 ± 1.20 | 10.59 ± 1.68 | 15.55 ± 1.85 | 36.80 ± 3.23 | |
| XRT (3 Gy) | 5.61 ± 0.87 | 9.09 ± 1.37 | 13.11 ± 2.16 | 25.27 ± 2.19 | .077 (1) |
| C225 (30 nM) | 5.17 ± 1.15 | 7.83. ± 1.47 | 11.07 ± 2.15 | 18.78 ± 3.55 | .001 (1) |
| Simvastatin (15 μM) | 2.04 ± 0.46 | 6.37 ± 1.73 | 9.32 ± 1.52 | 12.75 ± 2.37 | .001 (1) |
| XRT + C225 | 5.14 ± 1.05 | 8.93 ± 1.52 | 12.46 ± 1.73 | 21.66 ± 2.35 | .001 (1) |
| XRT + C225 + simvastatin | 4.20 ± 0.80 | 6.98 ± 1.36 | 9.43 ± 1.58 | 12.36 ± 1.78 | .001 (1) |
| .005 (2) | |||||
Cell cultures were treated as indicated in the Materials and Methods section. Values are means ± SE of three independent experiments, with each experiment duplicated. Doses used in the combined treatments are the same as in the single treatments. P value (Mann-Whitney test): (1) compared to nontreatment condition and (2) compared to XRT + C225.