Table 1.
Improved Arterial to Alveolar PO2 Ratios (A/A Ratio) After 24 H in PPHN Lambs Ventilated with 100% O2 in Combination with Nitric Oxide and/or Intratracheal Antioxidants
| Lamb | Treatment | a/A ratio±SEM | Reference |
|---|---|---|---|
| Control | O2 | 0.58±0.06 | (87) |
| PPHN | O2 | 0.19±0.08 | (87) |
| PPHN | O2+iNO | 0.51±0.1 | (87) |
| PPHN | O2+rhSOD | 0.48±0.12 | (87) |
| PPHN | O2+catalase | 0.50±0.25 | (162) |
| PPHN | O2+apocynin | 0.30±0.12 | (161) |
| PPHN | O2+hydrocortisone | 0.54±0.07 | (119) |
iNO, inhaled nitric oxide (20ppm); rhSOD, recombinant human superoxide dismutase (5 mg/kg), PEG-catalase (20,000 U/kg), apocynin (3 mg/kg), hydrocortisone (3×5 mg/kg).