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Effects of hyperoxia on NO-induced SNO uptake via LAT1. (A) Effects of 60% or 90% O2 exposure up to 12 h on NO treatment induced SNO accumulation in R3/1, L2, and A549 cells, (B) with the addition of 10 nM JPH203, (C) L-NAME, or (D) both. Results are mean of 6/group±SEM. *p<0.05 versus air, +p<0.05 versus corresponding 60% O2, Δp<0.05 added L-NAME versus corresponding treatment.
