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. 2014 Sep 9;4(9):e437. doi: 10.1038/tp.2014.77

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Copyright © 2014 Macmillan Publishers Limited

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/

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Corticosterone synthesis inhibitor blunts depressive-like behaviour in forced swimming test in n-3-deficient mice. n-3-deficient mice displayed (b) reduced swimming occurrence as compared with control diet mice. Metyrapone administration (75 mg kg⁻¹) 90 min before forced swimming test prevented depressive-like behaviour in n-3-deficient mice (interaction: F_1,27=7.486, P<0.05, two-way ANOVA; **P<0.01, Bonferroni's test, n=7–8 per group) that was not due to (a) locomotor activity changes (interaction: F_1,27=1.407, P>0.05, diet effect: F_1,27=1.795, P>0.05, treatment effect: F_1,27=0.06567, P>0.05, two-way ANOVA, n=7–8 per group). Data are displayed as mean±s.e.m.