Table 2. Path model of the effects of 5-HTTLPR genotype and brain ROIs on MDD onset.

	b	s.e.	β	P
Hippocampus
5-HTTLPR → MDD onset (path c′)	−0.21	0.17	−0.15	0.22
5-HTTLPR → left hippocampus (path a)	−0.08	0.03	−0.18	0.03
Left hippocampus → MDD onset (path b)	−1.79	0.79	−0.53	0.02
5-HTTLPR → right hippocampus (path a)	−0.05	0.04	−0.12	0.16
Right hippocampus → MDD onset (path b)	2.10	0.72	0.63	0.004
Amygdala
5-HTTLPR → MDD onset (path c′)	−0.17	0.16	−0.12	0.30
5-HTTLPR → left amygdala (path a)	0.01	0.02	0.04	0.66
Left amygdala → MDD onset (path b)	1.44	1.08	0.31	0.18
5-HTTLPR → right amygdala (path a)	0.02	0.03	0.07	0.42
Right amygdala → MDD onset (path b)	−1.23	0.88	−0.29	0.16
Medial OFC
5-HTTLPR → MDD onset (path c′)	−0.21	0.17	−0.15	0.23
5-HTTLPR → left medial OFC (path a)	−0.46	0.21	−0.21	0.03
Left medial OFC → MDD onset (path b)	−0.02	0.15	−0.04	0.88
5-HTTLPR → right medial OFC (path a)	−0.51	0.19	−0.25	0.006
Right medial OFC → MDD onset (path b)	−0.04	0.16	−0.05	0.83
Lateral OFC
5-HTTLPR → MDD onset (path c′)	−0.19	0.16	−0.13	0.25
5-HTTLPR → left lateral OFC (path a)	−0.10	0.37	−0.03	0.79
Left lateral OFC → MDD onset (path b)	−0.06	0.11	−0.15	0.59
5-HTTLPR → right lateral OFC (path a)	−0.01	0.32	−0.003	0.98
Right lateral OFC → MDD onset (path b)	0.06	0.12	0.14	0.61
Limbic ACC
5-HTTLPR → MDD onset (path c′)	−0.12	0.17	−0.08	0.49
5-HTTLPR → left limbic ACC (path a)	−0.39	0.20	−0.17	0.06
Left limbic ACC → MDD onset (path b)	0.16	0.08	0.27	0.04
5-HTTLPR → right limbic ACC (path a)	−0.33	0.22	0.01	0.87
Right limbic ACC → MDD onset (path b)	−0.02	0.08	−0.04	0.79
Paralimbic ACC
5-HTTLPR → MDD onset (path c′)	−0.17	0.16	−0.12	0.29
5-HTTLPR → left paralimbic ACC (path a)	0.13	0.23	0.05	0.58
Left paralimbic ACC → MDD onset (path b)	−0.09	0.08	−0.16	0.25
5-HTTLPR → right paralimbic ACC (path a)	0.05	0.22	0.02	0.82
Right paralimbic ACC → MDD onset (path b)	0.09	0.08	0.15	0.28

Abbreviations: ACC, anterior cingulate cortex; MDD, major depressive disorder; ROI, region of interest.