Table 5.
Curosurf poractant | Survanta beractant | Alveofact bovactant | Infasurf calfactant | |
---|---|---|---|---|
Doses | ||||
mg of PLs/kg | 200 | 100 | 100 | 100 |
ml of surfactant/kg | 2.5 | 4 | 2.2 | 2.86 |
SOD | ||||
U/mg of PLs | 0.396a | 0.474 | 0.027b | 0.383c |
U/ml of surfactant | 31.7 | 11.9 | 1.21 | 13.4 |
U/dose per kg | 73.3 | 47.6 | 2.6 | 38.3 |
CAT | ||||
nmol/min/ml of PLs | 0.81d | 2.60 | 1.58 | 3.23 |
nmol/min/ml of surfactant | 64.80 | 65.00 | 71.10 | 113.10 |
U/dose per kg | 149.80 | 260.00 | 157.80 | 323.50 |
Plasmalogens | ||||
mol% of total PLs | 3.8±0.1 | 1.5±0.2 | 0.9±0.3 | n.a. |
PUPLs | ||||
mol% of total PLs | 26±1 | 6±1 | 11±1 | n.a. |
p=0.019 versus Survanta.
p<0.0001 versus Survanta.
p=0.003 versus Survanta.
p<0.0001 versus Infasurf.
PLs, phospholipids; PUPLs; polyunsaturated phospholipids; n.a., not available.