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. 2014 Nov 1;21(13):1881–1892. doi: 10.1089/ars.2013.5791

FIG. 3.

FIG. 3.

Catalytic reaction of HO. Heme is degraded in an energy requiring process to biliverdin. This is then converted to bilirubin by the nonrate limiting biliverdin reductase. Iron (Fe) and carbon monoxide (CO) are released in equimolar amounts. To see this illustration in color, the reader is referred to the web version of this article at www.liebertpub.com/ars