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Maturational differences in HO-1 gene regulation and protein localization. In response to hyperoxia, neonates (left) do not up-regulate HO-1 mRNA but translocate HO-1 to the nucleus. In contrast, adults (right) induce HO-1 mRNA but do not translocate HO-1 to the nucleus. To see this illustration in color, the reader is referred to the web version of this article at www.liebertpub.com/ars
