FIG. 8.

Association of nuclear HO-1 with lung cancer. In both rodents and humans, increased nuclear distribution of HO-1 (inset on the right where DAPI nuclear stain and HO-1 are co-localized as shown by the cyan color) is associated with abnormal lung histology (as shown in the hematoxylin and eosin-stained tissue on the right). With cytoplasmic localization of HO-1 (left inset), lung tissue histology is more likely to be normal (left). To see this illustration in color, the reader is referred to the web version of this article at www.liebertpub.com/ars