Table 3.
Genotype/Allele Distributions of the PTK2 Gene and Results of Binary Logistic Regression Adjusted by Sex in the Japanese Cohort
| Cases | Controls | |||||||
|---|---|---|---|---|---|---|---|---|
| Model | rs7460 | n | % | n | % | Fisher exact test | OR (95% CI) | p value |
| Codom | A/A | 300 | 41 | 214 | 43 | 1 | ||
| A/T | 329 | 44 | 215 | 43 | 0.49 | 0.91 (0.7–1.2) | 0.67 | |
| T/T | 113 | 15 | 70 | 14 | 0.43 | 0.88 (0.6–1.3) | 0.46 | |
| Dom | A/A | 300 | 40 | 214 | 43 | 1 | ||
| A/T-T/T | 442 | 50 | 285 | 57 | 0.41 | 0.90 (0.7–1.1) | 0.38 | |
| Recess | A/A-A/T | 629 | 85 | 429 | 86 | 1 | ||
| T/T | 113 | 15 | 70 | 14 | 0.57 | 0.92 (0.7–1.3) | 0.63 | |
| Overdom | A/A-T/T | 413 | 56 | 284 | 57 | 1 | ||
| A/T | 329 | 44 | 215 | 43 | 0.68 | 0.94 (0.8–1.2) | 0.60 | |
| Log-add | — | — | — | 0.93 (0.8–1.1) | 0.39 | |||
| Allele | T | 555 | 37 | 355 | 36 | |||
| A | 929 | 63 | 643 | 64 | 0.37 | 0.93 (0.8–1.1) | 0.37 | |
| Cases | Controls | |||||||
|---|---|---|---|---|---|---|---|---|
| Model | rs7843014 | n | % | n | % | Fisher exact test | OR (95% CI) | p value |
| Codom | C/C | 435 | 59 | 272 | 54 | 1 | ||
| A/C | 254 | 34 | 189 | 38 | <0.001 | 1.18 (0.9–1.5) | 0.38 | |
| A/A | 53 | 7 | 38 | 8 | <0.001 | 1.15 (0.7–1.8) | 0.55 | |
| Dom | C/C | 435 | 59 | 272 | 55 | 1 | ||
| A/C-A/A | 307 | 41 | 227 | 45 | <0.001 | 1.18 (0.9–1.5) | 0.17 | |
| Recess | C/C-A/C | 689 | 93 | 461 | 92 | 1 | ||
| A/A | 53 | 7 | 38 | 8 | <0.001 | 1.08 (0.7–1.7) | 0.75 | |
| Overdom | C/C-A/A | 488 | 66 | 310 | 62 | 1 | ||
| A/C | 254 | 34 | 189 | 38 | 0.001 | 1.16 (0.9–1.5) | 0.21 | |
| Log-add | — | — | — | 1.12 (0.9–1.3) | 0.22 | |||
| Allele | C | 1124 | 76 | 733 | 73 | |||
| A | 360 | 24 | 265 | 27 | 0.20 | 0.89 (0.7–1.1) | 0.21 | |
Bold denotes p<0.05.
Of note, the results of the Fisher test remained unchanged when both sexes were analyzed separately (i.e., no significant p value was found).
codom, codominant; dom, dominant; recess, recessive; overdo, overdominant; Log-add, additive; %, relative frequency; 95% CI, 95% confidence interval; NA, not applicable; OR, odds ratio.