FIG. 1.

Placebo-adjusted least squares (LS) mean (95% CI) change from baseline in Conners' Parent Rating Scale–Revised: Short Form (CPRS–R:S) total scores at visit 10, last observation carried forward (LOCF): (A) across all three time points; (B) at morning assessment; (C) at afternoon assessment; and (D) at evening assessment. *p<0.001. GXR, guanfacine extended release. LS means and p values are based on type III sum of squares from an analysis of covariance (ANCOVA) model for the change from baseline, with treatment group as a fixed effect and baseline value as a covariate.