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IGFBP-1 inhibits the expression of MMP-9 in HCC cells (A and B). HepG2 and MHCC97-H cells were treated with IGFBP-1 at different doses (400 and 800 ng/ml) to evaluate the protein level of MMP-9. Non-treated cells served as controls. *P<0.05 compared to HepG2 cells non-treated with IGFBP-1, #P<0.05 compared to MHCC97-H cells non-treated with IGFBP-1.
