Table 2.
C-kit and VEGF immunohistochemical expression and different clinicopathological variables in retinoblastoma cases (n = 56)
| C-kit expression | VEGF expression | ||||||
|---|---|---|---|---|---|---|---|
|
|
|||||||
| Variable | n (%) | Negative n = 29 (51.8%) | Positive n = 27 (48.2%) | P-value | Negative n = 13 (23.2%) | Positive n = 43 (76.8%) | P-value |
| Pattern of growth | |||||||
| Endophyic | 21 (37.5%) | 16 (76.2%) | 5 (23.8%) | 0.002 (HS) | 5 (23.8%) | 16 (67.2%) | 0.51 (NS) |
| Exophytic | 4 (7.1%) | 0 (0.0%) | 4 (100.0%) | 0 (0.0%) | 4 (100.0%) | ||
| Combined | 31 (55.4%) | 13 (41.9%) | 18 (58.1%) | 8 (25.8%) | 23 (74.2%) | ||
| Degree of differentiation | |||||||
| Well & moderately differentiated | 36 (64.3%) | 16 (44.4%) | 20 (55.6%) | 0.98 (NS) | 7 (19.4%) | 29 (80.6%) | 0.26 (NS) |
| Poorly differentiated | 20 (35.7%) | 13 (65.0%) | 7 (35.0%) | 6 (30.0%) | 14 (70.0%) | ||
| Optic nerve invasion | |||||||
| Absent | 30 (53.6%) | 22 (73.3%) | 8 (26.7%) | 0.001 (HS) | 11 (36.7%) | 19 (63.3%) | 0.013* (HS) |
| Present | 26 (46.4%) | 7 (26.9%) | 19 (73.1%) | 2 (7.7%) | 24 (92.3%) | ||
| Choroidal invasion | |||||||
| Absent | 21 (37.5%) | 17 (81.0%) | 4 (19.0%) | ≤ 0.01 (HS) | 5 (23.8%) | 16 (76.2%) | 0.43 (NS) |
| Present | 35 (62.5%) | 12 (34.3%) | 23 (65.7%) | 8 (22.9%) | 27 (77.1%) | ||
n: number of cases, NS: non-significant, HS: highly significant;
*
fisher’s exact test.