Figure 1.

Isoflurane anesthesia induced spatial learning changes 2 weeks post anesthesia. Animals were exposed to 0.5MAC or 1MAC isoflurane for different time. 10 days later the Morris Water Maze was performed. A. The escape latency in the I₁ and I₂ group decreased significantly, I₄ group increased compared with the control group I₀ ( (I₁ VS I₀ ★p < 0.05, ★★p < 0.01; I₂ VS I₀ ﹟p < 0.05, ﹟﹟p < 0.01; I₄ VS I₀ ◆p < 0.05, ◆◆p < 0.01). B. I₁ and I₂ group increased numbers of cross platform significantly, while I₄ group decreased compared with the control group. There was no difference between group I₃ and control group (*p < 0.05, **p < 0.01).