Correlation of SPP1, PAI and caveolin-1 with Keap1, Nrf2 in human OSCC tissue array: A. SPP1 was found to be closely associated the PAI (P = 0.0001, r = 0.7042), Caveolin-1 (P = 0.0001, r = 0. 6968) and Keap1 (P = 0.0009, r = 0.4886 ), but not Nrf2 (P = 0.0890, r = 0.2625, A, Table 1), and PAI was strongly correlated with caveolin-1 (P = 0.0001, r = 0. 6734), Keap1 (P = 0.0001, r = 0. 6973) and Nrf2 (P = 0.0011, r = 0. 4822, A, Table 1), and caveolin-1 was associated with Keap1 (P = 0.0130, r = 0. 3759) and Nrf2 (P = 0.0559, r = 0. 2937, A, Table 1) in human OSCC tissue array; B. Hierarchical Clustering of Keap1, Nrf2 with SPP1, PAI and caveolin-1 in human OSCC tissue array. Histoscore based on quantification using Aperio quantification software and statistics with Graph Pad Prism5. Mean ± SEM; 2-tailed Pearson correlation statistics.