Table 2.
Prognostic factors in Cox proportional hazards model
| Variable | Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|---|
|
| ||||||
| Risk ratio | 95% CI | P | Risk ratio | 95% CI | P | |
| Gender | 1.173 | 0.619-1.587 | 0.594 | |||
| Male vs. Female | ||||||
| Age (years) | 1.439 | 0.517-1.894 | 0.264 | |||
| < 60 vs. ≥ 60 | ||||||
| Tumor size | 2.642 | 1.784-3.921 | 0.149 | |||
| < 4 cm vs. ≥ 4 cm | ||||||
| Histological grade | 5.264 | 3.976-12.043 | < 0.001 | 2.781 | 1.867-4.638 | 0.006 |
| G1 vs. G2-3 | ||||||
| Tumor stage | 3.796 | 2.117-6.484 | 0.013 | 2.966 | 1.937-6.714 | 0.021 |
| T1-2 vs. T3-4 | ||||||
| Lymph node | 5.108 | 2.974-8.265 | 0.015 | 3.681 | 2.171-4.472 | 0.031 |
| Absence vs. Presence | ||||||
| Clinical stage | 4.369 | 1.744-9.015 | 0.007 | 3.979 | 1.114-7.528 | 0.014 |
| I-II vs. III-IV | ||||||
| miR-335 | 5.718 | 2.219-9.448 | < 0.001 | 5.011 | 2.074-8.526 | 0.008 |
| high vs. low | ||||||
Abbreviations: CI, confidence interval; miR, microRNA.