Table 1.
Results of HER2 IHC and FISH with chromosome 17 aneuploidy in invasive ductal carcinomas with relation to tumor grade
| Tumor Grade | HER2 IHC | FISH | Chr 17 Aneuploidy | |
|---|---|---|---|---|
|
| ||||
| (n=390) | Score | No (%) | No. (%) | No. (%) |
| 1 (n=87) | Negative | 18 (21) | 2 (11) (amp) | 1 (50) |
| 16 (89) (nonamp) | 7 (44) | |||
| 2+ | 32 (37) | 3 (9) (amp) | 2 (66) | |
| 29 (91) (nonamp) | 13 (45) | |||
| 3+ | 37 (42) | 15 (41) (amp) | 1 (7) | |
| 22 (59) (nonamp) | 11 (50) | |||
| 2 (n=132) | Negative | 23 (17) | 2 (9) (amp) | 0 (0) |
| 21 (91) (nonamp) | 7 (33) | |||
| 2+ | 56 (42) | 8 (14) (amp) | 0 (0) | |
| 48 (86) (nonamp) | 25 (52) | |||
| 3+ | 53 (40) | 33 (62) (amp) | 1 (3) | |
| 20 (38) (nonamp) | 11 (55) | |||
| 3 (n=171) | Negative | 51 (30) | 3 (6) (amp) | 0 (0) |
| 48 (94) (nonamp) | 16 (33) | |||
| 2+ | 41 (24) | 11 (27) (amp) | 0 (0) | |
| 30 (73) (nonamp) | 13 (43) | |||
| 3+ | 79 (46) | 58 (73) (amp) | 1 (2) | |
| 21 (27) (nonamp) | 6 (29) | |||
Abbreviations: Amp, amplified; chr 17, chromosome 17; FISH, fluorescence in situ hybridization; HER2, human epidermal growth factor receptor 2; IHC, immunohistochemistry; nonamp, nonamplified.