Table 2.

41 gene mutations detected in BRCA1 exon 10

Base change	Codon encoded amino acid sites	Protein change	Mutation type*	N cases	Incidence % (N = 463)
1227th G > A	332	Arg→Gln	M	2	0.4
1268th C > T	346	Pro→Ser	M	1	0.2
1624th C > T	464	Thr→Thr	S	4	0.8
1633th G > A	467	Lys→Lys	S	1	0.2
2029th T > C	599	Asn→Asn	S	1	0.2
2238th T > C	669	Met→Thr	M	4	0.8
2309th G > A	693	Asp→Asn	M	1	0.2
2798th T > C	856	Tyr→His	M	8	1.7
2844th C > T	871	Pro→Leu	M	3	0.6
3236th C > T	1002	Asn→Asp	M	1	0.2
452th the beginning AGAAACA > TT	1083	Termination codon	N	1	0.2
3589th T > A	1119	Thr→Thr	S	1	0.2
3678th C > G	1149	Thr→Arg	M	1	0.2
3709th A > G	1159	Ile→Met	M	1	0.2
3971th G > A	1247	Val→Ile	M	5	1.1
3986th C > G	1252	Leu→Val	M	3	0.6
4030th C > G	1421	Ser→Arg	M	1	0.2
4200th started missing AAAT	1334	Termination codon	F	1	0.2

^*Mutation type: M missense mutation; S samesense mutation; N nonsense mutation; F frame-shifting mutation.