Table.
Summary of Phenotypic Findings
|
WT ND |
WT HF |
KO ND |
KO HF |
HF vs. ND, Nrf2−/− |
|
| Total eyes, n | 28 | 36 | 34 | 64 | |
| OCT | |||||
| n | 18 | 18 | 26 | 38 | |
| Subretinal drusenoid deposits | 1 | 3 | 9 | 22 | *P < 0.05 |
| Lesion progression | 1 | 0 | 2 | 12 | *P < 0.05 |
| Fundus examination | |||||
| n | 8 | 6 | 12 | 16 | |
| RPE mottling | 2 | 4 | 7 | 14 | |
| Drusen-like deposits | 1 | 5 | 8 | 13 | |
| Patchy lesions | 1 | 2 | 7 | 12 | |
| Histology | |||||
| n | 7 | 10 | 8 | 20 | |
| Pigmentary changes | 2 | 8 | 6 | 18 | |
| Vacuoles | 1 | 6 | 5 | 19 | |
| Drusen-like deposits | 0 | 1 | 5 | 10 | |
| CNV | 0 | 0 | 1 | 3 | |
WT, wild type; ND, normal diet; KO, knockout.
*
χ2 test between Nrf2 knockout mice on either control or high-fat diet.