Fig. 4.
Genome sequencing of isolates with a broad host range IncN plasmid. Color of title bar corresponds to the bacterial species from Fig. 1. Patient code or environmental isolate code and chromosome size denoted in each title bar. Detailed patient code, genus and species described in Table 1. Plasmids are colored to highlight three common backbones across isolates (red, pKpQIL; blue, pEC-IMP-like; green, pKPC-47e). The blaKPC genes are colored by allele type, KPC-2 is cyan and KPC-3 is magenta. Flanking sequences are colored to differentiate the bla gene context (red, Tn4401a; blue, Tn4401b; green, IS26-TnpA). Additional antibiotic resistance genes are marked in yellow.