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. Author manuscript; available in PMC: 2014 Oct 20.
Published in final edited form as: J Neurochem. 2004 Sep;90(5):1117–1131. doi: 10.1111/j.1471-4159.2004.02569.x

Fig. 3.

Fig. 3

Striatal H3 phospho-acetylation is selectively induced by D2-like antagonists. (a) Striatal immunoblots from mice killed 120 min after a single dose of D2-like agonist (quinpirole) or D2-like antagonist (raclopride) or saline. Blots were processed first for H3pS10-acK14 and then for H4acK12 immunoreactivity. Corresponding gel coomassie-blue stains for loading control show characteristic banding pattern of the four core histones, including H3, approximately 14.5 kDa, and H4, approximately 10.5 kDa. Notice increase in H3pS10-acK14, but not H4acK12 immunoreactivity in raclopride-treated animals. Notice that H3pS10-acK14 is unchanged in quinpirole-treated animals, in comparison to saline-treated littermates. (b) Levels of striatal H3pS10-acK14 immunoreactivity (mean ± S.E.M.) in D2-agonist (quinpirole)-treated animals, and in animals treated with raclopride or the atypical anti-psychotic risperidone. Levels are normalized to saline-treated littermate controls. There is an increase in striatal H3pS10-acK14 in raclopride- and risperidone-, but not in quinpirole-treated animals (*p < 0.05).