Skip to main content
. 2014 Aug 18;45(5):1829–1836. doi: 10.3892/ijo.2014.2605

Figure 2.

Figure 2

Diagram showing the genes involved in the fusions on the q arm of the chromosome 12, their orientations, locations and positions. The CDK4 and MDM2 genes are also included. The physical positions and the orientations of the genes are obtained from UCSC Genome Browser website (http://genome-euro.ucsc.edu/index.html) and they are based on the Human genome assembly of February 2009 (GRCh37/hg19). The colored arrows show the four fusion genes. The circle suggests a possible ring chromosome which leaves outside the CNTN1 gene. This ring chromosome closes between PTGES3 and PTPRB and would contain the PTGES3-PTPRB, HMGA2-DYRK2 and TMBIM4-MSRB3 as well as CDK4 and the amplified MDM2. Stars indicate positions of the partner fusion genes on chromosome 12, the CDK4 and MDM2 genes.