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. 2014 Sep 3;45(5):1847–1856. doi: 10.3892/ijo.2014.2634

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Copyright © 2014, Spandidos Publications

This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.

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Antitumor activity of γδ T cells and GPC3-specific CTLs in vivo. We subcutaneously inoculated (A) SK-Hep-1/vec or (B) SK-Hep-1/hGPC3 cells into NOD/SCID mice and intravenously injected effector cells. We performed adoptive cell transfer of expanded cells using five mice per group. Data represent the means ± SD. (A) The growth of SK-Hep-1/vec treated with CD8⁻ cells or all cells was significantly inhibited. The growth of SK-Hep-1/vec treated with CD8⁺ cells was not inhibited. (B) The growth of SK-Hep-1/hGPC3 treated with CD8⁺ or CD8⁻ cells was significantly inhibited. In addition, treatment with all cells, including both CD8⁺ and CD8⁻ cells, showed an additive inhibitory effect.