Fig. 1.

MK 801 inhibits haloperidol-mediatedc-fos gene expression. A, Haloperidol (0.3 and 1 mg/kg) induced c-fos gene expression in the striatum in a dose-dependent manner. B,c-fos induction after treatment with 0.3 mg/kg haloperidol (i.p.) was completely inhibited by MK 801 (1 mg/kg).C, c-fos induction after treatment with 1 mg/kg haloperidol was partially inhibited by MK 801. RNA blots with duplicate samples are shown. For a statistical analysis of multiple experiments, see Figure 4, A and B.