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Mutation of 896/897Ser–NR1 to alanine blocks forskolin-mediated gene expression. Primary striatal cultures were cotransfected with 3xCRE-luciferase and control expression vector, NR1 wild-type DNA (NR1wt), or mutated 896/897S/A DNA. Forskolin (2.5 μm) activated the 3xCRE-luciferaseconstruct. This activation was enhanced by cotransfection with wild-type NR1 and completely blocked by the mutated construct.Asterisks indicate statistically significant induction.n = 6.
