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. 2014 May 23;6(6):835–848. doi: 10.15252/emmm.201303374

Figure 5. Hematopoietic differentiation of gene-edited FA-IPSCs.

Figure 5

  1. Analysis of the percentage of CD43+CD34+, CD45+CD34+, and CD45+ cells generated by unexcised and excised geFA-iPSCs (clones 16 and Ex 16.1).
  2. Left: Representative pictures of hematopoietic colonies generated by geFA-iPSCs. Right: Analysis of the clonogenic potential of unexcised and excised ge-FAiPSCs (clones 16 and Ex 16.1) in comparison with H.D. cord blood cells.
  3. Survival to mitomycin C (MMC) of CFCs obtained from geFA-IPSCs (clone 16) in comparison with BM CFCs from two different FA patients (FA-664 BM and FA-82 BM) and with CFCs from a healthy cord blood (H.D. CB).

Data information: Values are shown as mean ± s.e. of three experiments. All P-values were calculated using two-tailed unpaired Student's t-test.