Table 4.
Multivariable RRsa (95% CIs) for use of all NSAIDs (aspirin, acetaminophen, other NSAIDs) and risk of ovarian cancer.
| Excluded medication use the 2 years before reference date | |||
|---|---|---|---|
| Cases | controls | RR (95% CI) | |
| All NSAIDs | |||
| Years of use | |||
| Neverb | 357 | 488 | 1.00 |
| 1 to 5 yr | 117 | 100 | 1.70 (1.22-2.36) |
| >5 to <=10 yr | 37 | 33 | 1.66 (0.98-2.83) |
| >10 yr | 79 | 57 | 1.85 (1.24-2.77) |
| P trend | <0.001 | ||
| # pills per week | |||
| Neverb | 355 | 486 | 1.00 |
| <=7/wk | 82 | 66 | 1.62 (1.11-2.39) |
| >7 to <=14/wk | 41 | 49 | 1.09 (0.67-1.78) |
| >14/wk | 110 | 74 | 2.24 (1.56-3.21) |
| P trend | <0.001 | ||
| Total # pills | |||
| Never | 355 | 486 | 1.00 |
| <=1096 | 73 | 63 | 1.60 (1.08-2.38) |
| >1096 to 6428 | 73 | 66 | 1.43 (0.96-2.13) |
| >6428 | 87 | 60 | 2.22 (1.49-3.31) |
| P trend | <0.001 | ||
| Years of use by type c Aspirin | |||
| Neverb | 492 | 597 | 1.00 |
| 1 to 5 yr | 46 | 25 | 2.13 (1.31-3.77) |
| >5 to <=10 yr | 13 | 18 | 0.70 (0.31-1.58) |
| >10 yr | 31 | 28 | 1.15 (0.62-2.13) |
| P trend | 0.14 | ||
| Acetaminophen | |||
| Neverb | 491 | 590 | 1.00 |
| 1 to 5 yr | 47 | 53 | 0.87 (0.53-1.41) |
| >5 yr | 44 | 25 | 1.71 (0.94-3.09) |
| P trend | 0.12 | ||
| Other NSAIDs | |||
| Neverb | 450 | 575 | 1.00 |
| 1 to 5 yr | 87 | 61 | 1.76 (1.18-2.63) |
| >5 yr | 17 | 19 | 1.18 (0.55-2.53) |
| >10 yr | 28 | 13 | 2.18 (1.03-4.63) |
| P trend | 0.008 | ||
| Frequency of use by type c Aspirin | |||
| Neverb | 492 | 597 | 1.00 |
| <=7/wk | 61 | 48 | 1.49 (0.94-2.35) |
| >7 to <=14/wk | 29 | 23 | 1.18 (0.61-2.29) |
| P trend | 0.21 | ||
| Acetaminophen | |||
| Neverb | 491 | 590 | 1.00 |
| <=7/wk | 48 | 45 | 1.04 (0.63-1.71) |
| >7 /wk | 43 | 33 | 1.36 (0.78-2.36) |
| P trend | 0.33 | ||
| Other NSAIDs | |||
| Neverb | 450 | 575 | 1.00 |
| <=7/wk | 52 | 38 | 1.56 (0.95-2.56) |
| >7 to <=14/wk | 29 | 25 | 1.27 (0.68-2.40) |
| >14/wk | 51 | 30 | 2.22 (1.30-3.79) |
| P trend | 0.0009 | ||
Adjusted for age, education, race, tubal ligation, family history of breast/ovarian cancer, menopausal status, use of oral contraceptives, parity, and talc use
Included subjects who started medication within 2 years of diagnosis/reference date
Additionally adjusted for the 4 types of medications simultaneously and history of PID, gonorrhea, ovarian cysts, endometriosis, and fibroids. The RRs for aspirin, acetaminophen and other NSAIDS were mutually adjusted. Aspirin included regular aspirin, buffered aspirin; acetaminophen included Tylenol, coricidin, Dristan, darvocet, Percocet, Excedrin; other NSAID included advil, nurin, clinoril, motrin, anaprox, feldene, indocin, naprosyn.