Table 2. Blood Toxicokinetic Parameters of DCP and ECH Following a Single Oral Administration of 50 mg/kg DCP in Male and Female Harlan Sprague–Dawley Ratsa.
| parameter | male rat | female rat |
|---|---|---|
| DCP | ||
| t1/2 (min) | 42.1 ± 1.61 | 43.8 ± 5.37 |
| Cmax (μM) | 251 ± 90.7 | 337 ± 133 |
| Cmax/D (μM kg/mmolb) | 648 ± 242 | 862 ± 325 |
| Tmax (min) | 12.5 ± 5 | 12.5 ± 5 |
| AUC(0–last) (μM min) | 17 714 ± 4562 | 19 978 ± 1467 |
| AUC(0–∞) (μM min) | 17 786 ± 4551 | 20 082 ± 1433 |
| AUC(0–∞)/D (μM min kg/mmol) | 45 873 ± 12 302 | 51 258 ± 2492 |
| Vz/F (L/kg) | 1.39 ± 0.334 | 1.23 ± 0.187 |
| ECHb | ||
| t1/2 (min) | 33.2 ± 6.97 | 47.9 ± 12.0 |
| Cmax (μM) | 0.0703 ± 0.0107 | 0.0623 ± 0.0132 |
| Tmax (min) | 10.0 ± 5.77 | 13.7 ± 11.8 |
| AUC(0–last) (μM min) | 3.50 ± 1.21 | 3.48 ± 0.81 |
| AUC(0–∞) (μM min) | 4.02 ± 1.15 | 4.67 ± 0.41 |
| Vz/F (L/kg) | 0.302 ± 0.093 | 0.288 ± 0.060 |
a
Average values (±SD) for n = 4 animals are reported.
b
Dose of DCP in mmol/kg was used.