Table 3. Blood Toxicokinetic Parameters of ECH Following a Single Oral Administration of 25 mg/kg ECH in Male and Female Harlan Sprague–Dawley Ratsa.
| parameter | male rat | female rat |
|---|---|---|
| t1/2 (min) | 33.8 ± 22.8 | 20.1 ± 13.6 |
| Cmax (μM) | 0.760 ± 0.218 | 0.233 ± 0.074 |
| Cmax/D (μM kg/mmol)b | 2.69 ± 0.76 | 0.857 ± 0.298 |
| Tmax (min) | 7.5 ± 2.9 | 5 ± 0 |
| AUC(0–last) (μM min) | 10.2 ± 1.92 | 3.28 ± 1.01 |
| AUC(0–∞) (μM min) | 12.1 ± 2.58 | 3.94 ± 1.06 |
| AUC(0–∞)/D (μM min kg/mmol) | 42.9 ± 9.13 | 14.4 ± 4.11 |
| Vz/F (L/kg) | 1146 ± 828 | 1956 ± 1267 |
a
Average values (±SD) for n = 4 animals are reported.
b
Dose of ECH in mmol/kg was used.