. 2014 Mar 21;57(8):3247–3262. doi: 10.1021/jm401688h

Table 2. NS5B Mutant Inhibition Parameters for Derivative 2a^a.

binding site	NS5B mutant	IC₅₀ (μM)	fold change
PSI	M414T	127.7 ± 5.5	29.7
TSI	P495L	5.1 ± 0.3	1.2
TSII	M423T	9.3 ± 1.5	2.2

The IC₅₀ values were evaluated against the indicated NS5B mutants as described for the wild-type NS5B and represents an average ± SD of two independent experiments in duplicate. Fold change is indicated relative to NS5B WT (IC₅₀ = 4.3 μM).

Table 2. NS5B Mutant Inhibition Parameters for Derivative 2aa.

Table 2. NS5B Mutant Inhibition Parameters for Derivative 2a^a.