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. Author manuscript; available in PMC: 2015 Nov 1.
Published in final edited form as: J Immunol. 2014 Nov 1;193(9):4283–4288. doi: 10.4049/jimmunol.1400864

Figure 1. Schematic of TSLP-regulated responses in tumors.

Figure 1

(1) Tumor or tumor-associated stromal cells produce TSLP, which promotes the maturation of resident dendritic cells through upregulation of costimulatory molecules, including OX40L; DCs drive the differentiation of Th2 cells through OX40/OX40L interactions (2); Th2 cells secrete IL4 and IL-13, leading to the recruitment and activation of MDSCs and tumor-associated macrophages (TAM;3), both of which are capable of effector T cell responses against the tumor (4); TAMs also produce factors that promote angiogenesis and matrix remodeling (5), while the tumor and associated stromal cells produce chemotactic and survival factors for the TAMs (6). Dotted line: proposed differentiation path.