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. Author manuscript; available in PMC: 2015 Nov 1.
Published in final edited form as: Immunol Rev. 2014 Nov;262(1):96–112. doi: 10.1111/imr.12213

Fig. 1. Cell type-specific selection of enhancers.

Fig. 1

Depiction of H3K4me2 ChIP-seq data obtained from mouse macrophages, T cells, and smooth muscles cells (SMC) in the vicinity of the Fos gene genomic locus. In macrophages, H3K4me2 peaks reveal an enhancer located 5kb upstream of the Fos transcription start site (TSS). This enhancer is also established in T cells but not in SMCs. On the other hand, T cells and SMCs each display a unique enhancer at 7kb and 10kb respectively. H3K4me2 marks are also present at promoters and may extend beyond the TSS at highly transcribed genes, reflecting high levels of transcriptional activity by RNAP II. Note that spacing between H3K4me2 peaks at enhancers is indicative of absence of nucleosome and concords instead with the binding of TFs.