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. Author manuscript; available in PMC: 2015 Oct 15.
Published in final edited form as: Cancer Res. 2014 Oct 15;74(20):5819–5831. doi: 10.1158/0008-5472.CAN-13-3527

Figure 2. Identification of compounds that rely on copper to inhibit the growth of prostate cancer cells.

Figure 2

(A) Chemical structure of the compounds identified. VCaP cells were treated for 72 hr. with increasing concentrations of DSF alone or in combination with sub toxic doses of the copper chelators TTM or BCS (B) or with PDTC alone or in combination BCS (C). D, 22RV1 cells were treated for 72 hr. with increasing concentrations of DSF alone or in combination with BCS. E, 22RV1 cells were treated for 72 hr. with increasing concentrations of MDV3100 alone or in combination with R1881. The AR negative PC3 (F) or the normal immortalized prostate RWPE-1 (G) cell lines were treated for 72 hr. with increasing concentrations of DSF alone or in the presence of the copper chelator BCS. The results from representative experiments are shown and are expressed as relative fluorescence ± SE (n=3).