Table 2. CAR-coding genes transfected/transduced so far into natural killer cells.

Target	Indication(s)	Blood NK cells	NK-92 cells	Refs.
CD19	Lymphoid malignancies	X	X	10,12–15
CD20	Lymphoid malignancies	X	X	16–18
CD38	Multiple myeloma		X	19
ERBB2	Breast carcinoma Head and neck cancer Ovarian carcinoma Glioblastoma	X	X	11,20
GD2	Neuroblastoma		X	21
EPCAM	Breast carcinoma Pancreatic cancer		X	22
EBNA3C	EBV infections		X	23
CS1	Multiple myeloma		X	24
LMAN1	Melanoma Neuroblastoma		X	25

Abbreviations: EBNA3C, Epstein-Barr nuclear antigen 3C; ERBB2, v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2; EPCAM, epithelial cell adhesion molecule; GD2, ganglioside GD2; LMAN1, lectin, mannose-binding, 1