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. 2014 May 20;10(8):1369–1379. doi: 10.4161/auto.29118

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Copyright © 2014 Landes Bioscience

This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.

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graphic file with name auto-10-1369-g3.jpg — Figure 3. Pharmacodynamic effects of TMZ and HCQ on autophagic vacuole accumulation in PBMC, and PK-PD correlation. (A) Mixed-effects model of mean ± SD autophagic vacuoles (AVs)/cell in PBMC. Dotted line: regression line. (B) Representative electron micrographs of serial PBMC; red arrows: AV (C) Classification tree from CART analysis. (D) Histogram of AV change at 2 wk in patients with estimated HCQ C_max above or below 1554 ng/mL.