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. 2014 May 20;10(8):1391–1402. doi: 10.4161/auto.29119

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Copyright © 2014 Landes Bioscience

This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.

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graphic file with name auto-10-1391-g2.jpg — Figure 2. Pharmacodynamic effects of temsirolimus and hydroxychloroquine on autophagic vacuole accumulation in peripheral blood mononuclear cells (PBMC). (A) Mixed-effects model of mean ± SD autophagic vacuoles (AVs)/cell. *P < 0.05. (B) Representative electron micrographs from a patient treated with TEM and TEM + HCQ 600 mg/po bid. Arrows, AVs; scale bar: 2 µm.