Table 2. Adverse events.

Daily HCQ dose	200 mg				400 mg				800 mg				1200 mg				Total
N	11				3				9				16				39
Adverse Event	G1–2	%	G3–4	%	G1–2	%	G3–4	%	G1–2	%	G3–4	%	G1–2	%	G3–4	%	G1–2	%	G3–4	%
Non-hematological toxicities
Anal fissure	-	-	-	-	-	-	-	-	1	11	-	-	1	6	-	-	2	5	-	-
Anorexia	4	36	-	-	1	33	-	-	5	56	1	11	6	38	2	13	16	41	3	8
Constipation	-	-	-	-	-	-	-	-	1	11	-	-	4	25	-	-	5	13	-	-
Diarrhea	3	27	-	-	1	33	-	-	1	11	-	-	2	13	-	-	7	18	-	-
Dizziness	-	-	-	-	-	-	-	-	-	-	-	-	2	13	-	-	2	5	-	-
Dysguesia	-	-	-	-	-	-	-	-	-	-	-	-	2	13	1	6	2	5	1	3
Elevated creatinine	-	-	-	-	-	-	-	-	-	-	-	-	2	13	1	6	2	5	1	3
Fatigue	5	45	-	-	2	67	-	-	2	22	2	22	10	63	1	6	19	49	3	8
Nausea	4	36	1	9	-	-	-	-	4	44	1	11	5	31	4	25	13	33	6	15
Poor wound healing	-	-	-	-	-	-	-	-	-	-	-	-	2	13	-	-	2	5	-	-
Rash	3	27	-	-	1	33	-	-	2	22	-	-	9	56	-	-	15	38	-	-
Stomatitis	4	36	-	-	1	33	-	-	4	44	-	-	7	44	-	-	16	41	-	-
Vitiligo	-	-	-	-	-	-	-	-	-	-	-	-	2	13	-	-	2	5	-	-
Weight loss	2	18	-	-	2	67	-	-	1	11	-	-	2	13	-	-	7	18	-	-
Hematological toxicities
Anemia	1	9	1	9	1	33	1	33	2	22	1	11	-	-	1	6	4	10	4	10
Neutropenia	1	17	-	-	-	-	-	-	-	-	-	-	-	-	-	-	1	3	-	-
Lymphopenia	5	45	-	-	1	33	-	-	3	33	-	-	6	38	1	6	12	31	1	3
Thrombocytopenia	4	36	1	9	-	-	-	-	2	22	-	-	2	13	-	-	8	21	1	3