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| HCQ dose cohort | N | PR | SD | PD | NE |
|---|---|---|---|---|---|
| Phase I dose escalation | |||||
| 200 | 6 | 0 | 4 | 2 | 5 |
| 400 | 3 | 0 | 3 | 0 | 0 |
| 800 | 9 | 0 | 5 | 4 | 0 |
| 1200 | 3 | 0 | 2 | 1 | 0 |
| Total | 21 | 0 (0%) | 14 (67%) | 7 (33%) | 5 |
| Melanoma patients | |||||
| 200–800 | 6 | 0 | 5 | 1 | 2 |
| 1200 | 13 | 0 | 9 | 4 | 1 |
| Total | 19 | 0 | 14 (74%) | 5 (26%) | 3 |
PR, Partial response; SD, stable disease; PD, progressive disease; NE, not evaluable
