Table 4. HCQ population pharmacokinetic parameters.
| Parameter | Model estimate | Bootstrap estimate | CV% | 95% CI |
|---|---|---|---|---|
| Ka (h) | 0.649 | 0.758 | 49.53 | 0.168–1.818 |
| V/F (L) | 864.639 | 496.0499 | 54.61 | 50.572–1093.471 |
| V2/F (L) | 3236.73 | 3285.0246 | 29.79 | 1747.053–5631.468 |
| Cl/F (L/h) | 17.517 | 15.953 | 19.23 | 9.118–19.920 |
| Q (L/h) | 26.067 | 26.421 | 38.50 | 8.067–54.496 |
| Tlag (h) | 0.399 | 0.564 | 48.52 | 0.181–1.191 |
| Stdev | 350.719 | 317.599 | 34.94 | 113.777–531.154 |
Stdev, standard deviation; CV, coefficient of variation; CI, confidence interval; L, liters; h, hours; Ka, absorption rate constant; V/F, apparent central volume of distribution; V2/F, apparent peripheral volume of distribution; Cl/F, apparent oral clearance; Q, intercompartmental clearance; Tlag, absorption lag time