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. 2014 Oct 21;186(15):E579–E586. doi: 10.1503/cmaj.122037

Table 2:

Therapeutic options for systemic features in Sjögren syndrome59,66,72,73

Feature Therapy
Nonspecific symptoms
 Fatigue

  • Antidepressants, exercise
 Raynaud phenomenon

  • Avoidance of cold and stress; calcium-channel blockers
 Arthralgia, arthritis

  • Nonsteroidal anti-inflammatory drugs, hydroxychloroquine, methotrexate
Periepithelial involvement
 Interstitial nephritis-tubular dysfunction, renal tubular acidosis

  • Oral potassium and sodium carbonate
 Bronchial or bronchiolar involvement

  • Inhaled therapy
 Interstitial lung disease

  • Prednisolone, azathioprine
 Primary biliary cirrhosis

  • Ursodeoxycholic acid
 Autoimmune hepatitis

  • Prednisolone, azathioprine
Immunocomplex-associated disease
 Peripheral neuropathy

  • Intravenous gamma globulin

  • Rituximab

  • Plasma exchange
 Vasculitis

  • Prednisolone

  • Cyclophosphamide

  • Rituximab

  • Plasmapheresis
 Glomerulonephritis

  • Prednisolone, intravenous cyclophosphamide
 Central nervous system disease

  • Pulse steroids

  • Prednisolone

  • Cyclophosphamide

  • Azathioprine