Skip to main content
. Author manuscript; available in PMC: 2014 Nov 1.
Published in final edited form as: Lung Cancer Manag. 2014 Jan 1;3(1):67–75. doi: 10.2217/lmt.13.72

Figure 2. Targeted inhibitors of PI3K/AKT/mTOR signaling pathway.

Figure 2

Arrows represent activation, whereas the dashed bar represents negative feedback and the solid bars indicate the targets of pharmacological inhibitors.

IRS: Insulin receptor substrate; mTORC2: mTOR complex 2; mTORC3: mTOR complex 3; PDK1: Phosphoinositide-dependent kinase 1; PIP2: Phosphatidylinositol bisphosphate; PIP3: Phosphatidylinositol triphosphate; PTEN: Phosphatase and tensin homolog; RTK: Receptor tyrosine kinase.