Table 1. Characteristics of studies.
Study | Genotyping platform | Case/Controlwith genetic data | Case/control after QC* | No of SNPs after QC | No of imputed SNPs§ | No of imputed rare (MAF≤3%) SNPs§ |
ADNI | Illumina Human610-Quad | 350/169 | 350/169 | 533479 | 16242208 | 8608819 |
ADNI2 | Illumina GenomeStudio v2009.1 | 53/125 | 53/125 | 634701 | 14860121 | 7257490 |
GenADA | Affimetrix Mapping250K_NspMapping250K_Sty | 782/806 | 779/803 | 432763 | 14441395 | 6863818 |
eMERGE | Illumina Human660W-Quad_v1_A | 676/1843 | 632/1843 | 535401 | 16190257 | 8572925 |
NIA-LOAD | Illumina Human610-Quad_v1_B | 2244/2320 | 2098/2095 | 542080 | 19568275 | 11943583 |
Framingham | Affimetrix Mapping250K_NspMapping250K_Sty | 314/4711 | 259/4323 | 371114 | 16510848 | 8908801 |
* In addition to genotyping QC, we selected only European ancestry without missing information on age and sex.
SNPs with INFO≥0.4.