Table 4. Results of gene-based rare allele analysis top ranking genes in the AlzGene database.

Gene	CHR	start	Meta Z	Meta P	Directions*
ABCA7	19	1040101	0.2	0.8539	+++–+
PICALM	11	85668485	–0.4	0.7068	–?+–+–
CLU	8	27454450	–1.1	0.2554	–++–
MS4A6A	11	59939080	0.5	0.6377	–+–+–+
CD33	19	51728334	–0.4	0.7185	–++–
BIN1	2	127805606	2.0	0.0460	++++–
MS4A4E	11	59980567	0.5	0.6377	–+–+–+
CR1	1	207669472	0.7	0.5050	++–+–+
CD2AP	6	47445524	–1.1	0.2593	–+–+

Protein names: ATP-binding cassette, sub-family A, ABCA7; phosphatidylinositol binding clathrin assembly protein, PICALM; clusterin, CLU; membrane-spanning 4-domains, subfamily A, member 6A, MS4A6A; CD33 molecule, CD33; bridging integrator 1, BIN1; putative membrane-spanning 4-domains subfamily A member 4E, MS4A4E; complement component (3b/4b) receptor 1, CR1; CD2-associated protein, CD2AP.

* The signs represent those of the Z score of each study. The question mark represents missing data in the study because of low INFO or high MAF. The order of the signs is ADNI, ADNI2, GenADA, eMERGE, NIA, and Framingham study.