Skip to main content
. Author manuscript; available in PMC: 2014 Oct 20.
Published in final edited form as: J Cancer Ther. 2014 May 16;5(6):506–516. doi: 10.4236/jct.2014.56058

Figure 2.

Figure 2

WT p53 interacts with the Drosha complex in the ovarian cancer cell line UCI-107. (a) Co-immunoprecipitation (Co-IP) experiments demonstrated an interaction between WT p53 and the Drosha complex. IPs were performed with antibodies to Drosha, DDX5, or p53. Conversely, IP of IgG did not detect any of these proteins binding to it. (b) A model representing the role of WT p53 in post-transcriptional up-regulation of tumor suppressive miRNAs. After DNA damage, p53 accumulates and is relocated to the nucleus, where it can bind to the Drosha complex and enhance the rate of miRNA processing of select miRNAs.