Table 1.

TP53 mutations in endometrial carcinomas and advanced serous ovarian cancers. Exon sequencing data downloaded from the TCGA data portal was used to annotate TP53 mutation types in endometrial cancers and advanced serous ovarian cancers (Brachova et al., Gynecologic Oncology, submitted). LOF = loss of function or null; WT = wild type; oncomorphic = gain of function or oncogenic; unclassified = single point mutations not previously categorized as gain of function (GOF) or oncomorphic.

Endometrial Cancer			Ovarian Cancer
TP53 mutation classification	Counts	Percent	TP53 mutation classification	Counts	%
Oncomorphic	23	32.4	Oncomorphic	56	21.2
LOF	15	21.1	LOF	50	18.9
Unclassified	31	43.7	Unclassified	156	59.1
WT	2	2.8	WT	2	0.8
Total	71	100		264	100