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. Author manuscript; available in PMC: 2015 Nov 1.
Published in final edited form as: J Hepatol. 2014 Jun 16;61(5):1126–1134. doi: 10.1016/j.jhep.2014.06.009

Figure 4. Amitriptyline protects wild type mice from HFD-induced NASH.

Figure 4

Wild type mice were fed RD or HFD with or without amitriptyline (AMI) for the last 6 weeks to determine oil red staining (A), TG (B), cholesterol (C), FFA (D), H&E (E), serum ALT (F), Col1A mRNA levels (G), Sirius Red staining (H) or MCP-1 expression (I). J, schematic summary of the findings: ASMase promotes HFD-induced ER stress, autophagy and LMP, which in turn, contribute to steatosis and lipototoxicity. ASMase ablation prevents these effects induced by HFD. The dash line linking autophagy and fatty liver denotes that this relationship may not be direct in view of recent findings (see Discussion). Results are expressed as mean ± SD of n=10 mice per group. * p<0.05 vs. control mice fed RD; #p<0.05 vs. control mice fed HFD.