Table 2. The top 20 interaction terms after replication.
| Interaction | Direction of βint ** | Meta-analysis of RS-I, RS-II and RS-III | Meta-analysis of replication cohorts | ||||||||||||
| βint | SE | p-value | βint | SE | p-value | ||||||||||
| rs2315598–rs2853228 | + | + | + | − | − | − | − | + | − | 0,1123 | 0,0193 | 5,91E-9 | −0,0178 | 0,0067 | 0,0076 |
| rs6848132–rs7863451 | − | − | − | − | − | − | − | − | − | −0,1077 | 0,0181 | 2,76E-9 | −0,0158 | 0,0060 | 0,0081 |
| rs3756856–rs11758333* | − | − | − | + | + | − | + | − | + | −0,0769 | 0,0132 | 5,33E-9 | 0,0112 | 0,0047 | 0,0160 |
| rs4596126–rs11676467 | + | − | + | − | + | + | + | + | + | 0,0973 | 0,0175 | 2,47E-8 | 0,0137 | 0,0068 | 0,0436 |
| rs871849–rs9672547 | − | − | − | − | − | − | − | − | + | −0,0820 | 0,0141 | 5,86E-9 | −0,0092 | 0,0048 | 0,0557 |
| rs5018943–rs7023148 | − | − | − | + | − | − | − | − | − | −0,0944 | 0,0159 | 2,96E-9 | −0,0132 | 0,0069 | 0,0558 |
| rs2280518–rs9875407 | + | + | + | + | + | + | + | + | + | 0,1393 | 0,0242 | 9,22E-9 | 0,0161 | 0,0085 | 0,0574 |
| rs754950–rs10926977 | + | + | + | − | − | − | + | − | − | 0,0876 | 0,0148 | 2,92E-9 | −0,0103 | 0,0055 | 0,0608 |
| rs2301818–rs7537266 | − | − | − | − | + | − | + | + | + | −0,0905 | 0,0156 | 6,43E-9 | 0,0098 | 0,0053 | 0,0626 |
| rs10816852–rs10911901 | + | + | + | + | + | + | + | − | − | 0,1491 | 0,0257 | 6,45E-9 | 0,0135 | 0,0075 | 0,0734 |
| rs645925–rs12231356 | + | + | + | − | − | − | − | + | + | 0,1102 | 0,0184 | 2,04E-9 | −0,0112 | 0,0063 | 0,0749 |
| rs820065–rs7762721* | − | − | − | − | − | − | + | − | + | −0,0768 | 0,0132 | 5,36E-9 | −0,0082 | 0,0046 | 0,0782 |
| rs7214582–rs17075071 | + | + | + | − | − | + | − | − | − | 0,2005 | 0,0349 | 9,40E-9 | −0,0190 | 0,0109 | 0,0817 |
| rs774801–rs12442098 | − | − | − | − | − | + | − | + | − | −0,0960 | 0,0167 | 8,57E-9 | −0,0101 | 0,0059 | 0,0866 |
| rs693–rs4677039 | + | + | + | + | + | + | + | + | − | 0,0570 | 0,0102 | 2,07E-8 | 0,0057 | 0,0034 | 0,0928 |
| rs3756856–rs7762721* | − | − | − | − | + | + | − | − | + | −0,0836 | 0,0131 | 1,82E-10 | 0,0078 | 0,0046 | 0,0928 |
| rs2242312–rs11190870 | + | + | + | + | + | − | + | − | − | 0,1238 | 0,0205 | 1,65E-9 | 0,0112 | 0,0067 | 0,0951 |
| rs3756856–rs6940398* | − | − | − | − | + | − | − | + | + | −0,0793 | 0,0131 | 1,61E-9 | 0,0078 | 0,0047 | 0,0982 |
| rs2316640–rs10973877 | + | + | + | + | − | + | − | − | + | 0,0729 | 0,0122 | 2,08E-9 | −0,0064 | 0,0039 | 0,0990 |
| rs2234044–rs7762721* | − | − | − | + | + | − | − | − | + | −0,0807 | 0,0132 | 1,10E-9 | 0,0075 | 0,0046 | 0,1044 |
The interactions are sorted based on the p-value of the interaction term βint. The HDL levels are adjusted for sex and age. The phenotypes of the Rotterdam Study are not scaled around zero.
*Interaction terms in LD with each other (R 2>0.872).
**order of the directions: AGES, ARIC, CHS, ERF, FHS, NFBC-66, RS-I, RS-II, RS-III. The meta-analysis was done with fixed effects.