Table 3. Gominer Analysis based for over-expressed genes in PAH signature versus HC.

GO ID	GO category	Number of significant genes	Enrichment	FDR
GO:0032501	multicellular organismal process	323	1.29	0.00
GO:0007608	sensory perception of smell	18	4.28	0.00
GO:0003008	system process	104	1.65	0.00
GO:0007275	multicellular organismal development	243	1.33	0.00
GO:0007606	sensory perception of chemical stimulus	20	3.40	0.00
GO:0032502	developmental process	259	1.28	0.00
GO:0007186	G-protein coupled receptor protein signaling pathway	57	1.85	0.00
GO:0048731	system development	201	1.33	0.00
GO:0048856	anatomical structure development	219	1.30	0.00
GO:0050877	neurological system process	74	1.65	0.00
GO:0009187	cyclic nucleotide metabolic process	21	2.61	0.00
GO:0009190	cyclic nucleotide biosynthetic process	19	2.75	0.01
GO:0048513	organ development	141	1.36	0.01
GO:0030154	cell differentiation	150	1.34	0.01
GO:0030218	erythrocyte differentiation	16	2.90	0.01
GO:0031279	regulation of cyclase activity	14	3.12	0.01
GO:0030802	regulation of cyclic nucleotide biosynthetic process	16	2.85	0.01
GO:0030808	regulation of nucleotide biosynthetic process	16	2.85	0.01
GO:0007155	cell adhesion	65	1.58	0.01

Only GO categories enriched in cluster C with FDR less than 1%, with enrichment superior to 2 and with more than 10 genes are displayed.